In recent studies cannabidivarin (CBDV) is demonstrating anticonvulsant effects but could also play a strong role as an anti-nausea treatment. Studies on both of these CBDV effects have been completed with impressive results and further research underway/planned. Tests in vitro show that CBDV can suppress epileptic triggers with research into the exact mechanisms ongoing. It is thought that TRPV1 (Transient Receptor Potential Vanilloid 1) channel desensitization is the primary mechanism by which seizures could be reduced/inhibited altogether.
There’s good news for those looking to lose weight too. CBDV has shown to be an appetite suppressant with none of the side effects that are inherent in most pharmaceutical treatments1. In addition, as anecdotal evidence abounds, CBDV is an effective remedy for nausea symptoms. Below you can read how this is now scientifically recognized as an effect of CBD/CBDV.
The molecular structure of CBDV is a homolog of cannabidiol (CBD), with the side-chain shortened by two methylene bridges (CH2 units). CBDV has 30 stereoisomers and 7 double bond isomers. Cannabidivarin (CBDV) has a molecular structure very similar to cannabidiol (CBD). It is the precursor to the mildly psychoactive cannabinoid, tetrahydrocannabivarin (THCV).
Epilepsy and CBDV
Abstract from an NIH article where CBDV was used to try and mitigate epileptic activity2
Cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro
“Epilepsy is the most common neurological disorder, with over 50 million people worldwide affected. Recent evidence suggests that the transient receptor potential cation channel subfamily V member 1 (TRPV1) may contribute to the onset and progression of some forms of epilepsy. Since the two non-psychotropic cannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) exert anticonvulsant activity in vivo and produce TRPV1-mediated intracellular calcium elevation in vitro, we evaluated the effects of these two compounds on TRPV1 channel activation and desensitization and in an in vitro model of epileptiform activity”
Although quite a difficult read, the article holds strong promise for CBDV to act as an inhibitor for the neural activity that triggers an epileptic seizure. Their conclusion was that although these results are impressive, they were performed on a epileptiform cell culture (in vitro). Further studies were recommended and indeed are ongoing by pharmaceutical companies who are studying CBDV with a view to finding solutions for treating epilepsy.3,4
Nausea and CBDV
A Canadian study5 compared cannabidivarin CBDV & Cannabidiol CBD with Rimonabant a drug which failed to gain FDA approval for use in the USA. It was found that CBDV was a useful alternative treatment. Rimonabant was marketed as an appetite suppressant but turned out to be unsuitable due to problems with unacceptable side effects. It turns out that CBDV has similar appetite suppressant abilities, but with no discernable side effects at all.
The study also tested rats (who have been given an emetic to induce nausea) for nausea reduction using THCV and CBDV. The results showed a significant reduction in nausea symptoms
The next step of the study was to test the effect of cannabinoids on nausea. Researchers induced nausea in the rats with a toxin and treated them with 10-20 mg of THCV or CBDV. According to their results, both cannabinoids reduced the rats’ experience with nausea.
Diseases currently treated with cannabidivarin CBDV
There are a number of conditions which are being treated with CBD and CBDV. There is also with ongoing research into how these cannabinoids help remit and sometimes inhibit symptoms and disease progress. There are many success stories for those who used hemp extract to reduce their suffering for diseases such as:
- Multiple Sclerosis
Elixinol is a full-spectrum hemp extract and we champion the purity and quality of CBD in our products. The good news is that because we use a whole-plant organic extract, our products also contain CBDV so could be administered to those suffering severe nausea or epileptic seizures. For those who might have used help or cannabis for nausea reduction this will not be news as this property has been known for some time. The Canadian study discussed above concluded that more research was required to determine how best to use cannabinoids like CBDV in an anti-nausea treatment.
If you would like to purchase hemp oil extract which contains CBD and CBDV, please visit our products page.