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How CBD works

whole-plant hemp oil

Whole-plant Hemp Oil CBD vs Isolates and Nanotechnology

By | How CBD works | No Comments

You’ve heard about the ‘entourage effect,’ right?

This is the notion (more than a notion, a demonstrated truth, actually) that the various compounds and terpenes in cannabis work synergistically, amplifying each other’s power and positive benefits. Like a symphony orchestra, cannabinoids including CBD, CBN and others combine forces in ways that enable them to become greater than the sum of their parts. But the key, like that collection of orchestral instruments, is that they work together only when you are exposed to them at the same time. This orchestra of cannabinoid components is what whole-plant hemp oil provides.

That’s the genius of hemp

There is a school of thought however, that it’s better to find and isolate the key ingredient, mass produce it and then pump our bodies full of that specific molecule. Why send the infantry, artillery and the whole dang Army if you can parachute in a few specialists to who will get the job done?

Even better, by this way of thinking, we now have the technology to shrink the needed elements down to nano size. Thus, through delivery methods that bypass the stomach (sublingual tincture and vaping), you can get molecules of pure CBD isolate into your bloodstream so they can get to work. What could be better?              

Sometimes less is more

Well, as noted above, if you consume pure CBD isolate, you may well be cheating yourself out of the primary benefits whole-plant hemp oil has to offer. As explained in a post at Project CBD:

“But single-molecule CBD is less effective therapeutically than whole plant CBD-rich oil extract. Scientific studies have established that synthetic, single-molecule CBD has a very narrow therapeutic window and requires precise, high doses for efficacy, whereas lower dose, whole-plant, CBD-rich treatment regimens are already showing efficacy for many conditions among patients in medical marijuana States…

There are also many Internet storefronts touting the ‘nano technology’ they use to produce extremely small emulsified droplets that are more readily absorbed. But there are questions about this too.

From a story at TodaysDietitian.com:

“Increasing the bioavailability of nutrients and phytochemicals may be promising but is also potentially dangerous.” Mark Meskin, PhD, RD, FADA, professor emeritus of the Department of Human Nutrition & Food Science at the California State Polytechnic University in Pomona, says nanotechnology may solve absorption and solubility problems with many nutrients and phytochemicals.” But he notes that this is a clear example of technology getting well ahead of the science.”

Even though the use of nanotechnology in the dietary supplement industry may enhance supplement absorption, there is concern about the potential for toxicity. While upper limits are established for most vitamins and minerals, there are no upper limits set for non-nutrients such as phytochemicals.

“In the past, I was less concerned about phytochemical toxicity because the truth was that in many cases, very little was absorbed,” Meskin says. 

Nanotechnology raises important issues regarding safety. He explains “nanoceuticals can help bypass typical protective barriers in the body and deliver quantities of biochemicals that the body would not naturally encounter. This makes the introduction of nanoceuticals potentially dangerous, especially when the government does not regulate them effectively.”

So if nanoceuticals could be dangerous, should you be vaping tinctures and oils that include them? What’s the takeaway here for the consumer who wants to take advantage of the health benefits of CBD?

Educate yourself about whole-plant hemp oil and pay attention.

Despite 40,000 years of human experimentation with cannabis, only in the last 20 years have we learned about the existence of the endocannabinoid system in our bodies. Research about the effects of CBD and other cannabinoids is ongoing. Stay tuned, and in the meantime, remember this: Our bodies have a relationship with the whole plant. Therefore, stick to whole-plant hemp oil formulations like Elixinol until the research catches up with the nano trend. 

If you want to vape your CBD or ingest it sublingually, Respira from Elixinol is made from organically grown hemp plants, and cold-processed using co2 super-critical fluid extraction. It’s PG- and PEG-free, and a THC-free, whole-plant product.  Try it today!

 

Leonard Marshall

Elixinol Congratulates Leonard Marshall on His Commitment to CTE Research

By | How CBD works, Industry Events | No Comments

Research into the effects of cannabidiol and CBD hemp oil is something Elixinol has always supported and encouraged internationally. We believe in a science-based approach to wellness. It’s with this in mind that we congratulate Elixinol Brand Ambassador, Leonard Marshall on his decision to donate his brain to scientific research for Chronic Traumatic Encephalopathy (CTE). According to protectthebrain.org, traumatic brain injuries cause more than 1.5 times more deaths than AIDS. However, research into the most serious effects of brain injuries is incomplete. This makes Marshall’s commitment to CTE research even more compelling. Read More

Why Does CBD Have So Many Potential Uses?

By | Cannabinoids explained, Health effects of cannabinoids, How CBD works, Uncategorized | No Comments

CBD is a Unique Molecule With Many Potential Uses

Here at Elixinol, we have covered a wide range of potential therapeutic uses for cannabidiol (CBD), other cannabinoids and hemp oil. From epilepsy to PTSD, it can all sound too good to be true. So how could one plant have so many benefits?

many uses of CBD

Besides being the second most abundant cannabinoid in the Cannabis genus, and the most in hemp, CBD is now well-known for the sheer number of possible therapeutic uses1. Each use has different levels of evidence, from clinical trials where we see how effective it is in humans, to in vitro lab studies where we can see how it may work. The presence of endocannabinoid receptors in a range of tissues and organs help to explain CBD’s broad applications. However, it can also interact with other types of receptors in the body and brain. Endocannabinoid-CBD-PTSD

The brain seems to be built for cannabinoids

The brain is made up of billions of highly specialised cells called neurons, along with several types of supporting cell2. Each neuron communicates with many other neurons by the synapses. Synapses are where two tiny bulbs on the ends of projections from the neuron cell come to meet. Neurons communicate with these by using chemicals known as neurotransmitters. Whether or not a neuron can “understand” the use of a certain neurotransmitter depends on if it has a receptor for that chemical. These receptors can respond to other chemicals too, such as the cannabinoids.

CBD increases the level of our own Cannabinoids

CBD, unlike THC, does not directly interact with the cannabinoid receptors, but instead works to increase the levels of our own cannabinoids. It also indirectly affects the signaling of these receptors. One of the non-cannabinoid receptors that CBD can influence is the dopamine receptors. Dopamine is involved with motivation and reward, as well as other cognitive and motor functions. This may be behind how CBD could help to fight cigarette cravings. In a study of 24 cigarette smokers, volunteers were given either an inhaler with CBD, or a placebo inhaler, and instructed to use it whenever they craved a cigarette3. The number of cigarettes smoked in the CBD group dropped significantly during the week, but not for the placebo group.

CBD and Serotonin

Animal studies have also shown that CBD can interact with some types of serotonin receptors, which may explain its effects on depression and anxiety. Its ability to interact with the serotonin 1A receptor may explain the documented effects of CBD on neuropathic pain, opioid dependence, and nausea and vomiting. There have been many anecdotal reports of hemp oil relieving nausea, even in severe vomiting caused by pharmaceuticals used for cancer. In addition, a study on shrews showed an effect of CBD on the serotonin 1A receptors which significantly reduced nausea and vomiting4. Its non-heated form, CBDA, had the same effect, but at a much lower dose.

Supporting the wide-ranging effects of CBD are the other cannabinoids, such as CBG and CBC, terpenes and other phytochemicals. These have shown anti-inflammatory, antidepressant, antioxidant and other effects. The number of potential benefits of hemp oil and CBD aren’t exactly “too good to be true”, but clinical trials are needed to confirm many of them.


References

1: https://www.leafly.com/news/science-tech/what-does-cbd-do

2: Tortora & Derrickson, 2012, Principles of Anatomy & Physiology, 12th edn, Wiley

3: http://www.ncbi.nlm.nih.gov/pubmed/23685330

4: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960260/

5: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

Hemp Oil Uses

Hemp Oil Uses & Dіеtаrу Benefits

By | How CBD works | No Comments

Hеmр oil uses are extremely varied. Hemp seed oil, ехtrасtеd dіrесtlу frоm thе sееds of industrial hemp, іs mоstlу used for bоdу саrе рrоduсts, оr іndustrіаllу іn lubrісаnts, fuеls, раіnts аnd рlаstісs. Ноwеvеr, thе bеnеfіts оf соnsumіng hеmр sееd оіl also саnnоt bе іgnоrеd. Read More

drug test cbd

Will I Pass a Drug Test if I Take CBD Hemp Extracts?

By | Cannabis Legislation, How CBD works | 9 Comments

The difference between many medicinal hemp products and recreational cannabis is that the former can contain little to no THC, the psychoactive component of cannabis.  A common concern among many who use hemp extracts is the possibility of testing positive for cannabis use in the workplace or at a roadside drug test. This could mean facing legal action, unemployment or both.

Are these fears unfounded or must we wait for clear legalisation before starting any form of medicinal hemp / CBD oil? Read More

How Does Cannabidiol (CBD) Work?

By | How CBD works | 11 Comments

Before making the decision to buy CBD oil, I strongly recommend you to take the time to learn more about cannabidiol and our product and to get familiar with the numerous benefits of cannabinoids on the human body. We’ve already discussed some of these benefits in previous articles, so right now it’s time to take a closer look at how CBD works inside the human body.

CBD’s action inside the body

CBD or cannabidiol is the main active compound in hemp and unlike THC, it is not psychoactive, so it doesn’t make you high. As you may know, inside the human body there’s the endocannabinoid system, with receptors spread throughout the brain and body. THC activates the CB1 and CB2 receptors, while CBD does not directly stimulate these receptors. Read More