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How CBD works

Dogs and CBD

Dogs and CBD Treats Recent Study From American Holistic Veterinary Medical Association

By | How CBD works | No Comments

dogs and CBD oilAs dog owners, we struggle with deciphering our dog’s emotions, especially when it comes to challenging behaviors like separation anxiety and incessant barking and more complicated disorders such as cancer and arthritis. Wouldn’t it all be easier if we could communicate with our dog and they could tell us where it hurt?

While CBD oil can’t magically teach your dog English, dog owners are increasingly reaching for CBD-laced treats to relieve pet discomfort and help with a wide range of ailments. It’s all due to the endocannabinoid system (ECS) we share with our canine friends.

Mammals all have an ECS

Every mammal has receptors in its body for cannabinoids —  chemical compounds that are found in hemp. When these non-psychoactive compounds interact with the ECS, they help govern the body’s appetite, sleep, mood and memory. This interaction is also involved in how our bodies fight inflammation, the perpetrator in many diseases.

A recent survey study conducted by American Holistic Veterinary Medical Association reported that 61.8% to 95% of pet owners have endorsed the health benefits of CBD-laced treats, ranging from ‘moderate to excellent’. Some of the medical conditions that were relieved by these edible treats include pain, nervous system problems, inflammation, anxiety, vomiting, digestive system problems, tumors, seizures/convulsions, skin problems and phobias, including fireworks or thunderstorm phobias.

If you are considering giving dogs CBD, there are a few things to remember:

  1. CBD Hemp Oil will not get your pet high. It does not contain THC and does not have psychoactive properties.
  2. Pay attention to how the CBD oil is extracted. At Elixinol, we use the “whole plant.” Using the “whole plant,” allows us to extract the variety of constituents (more than 500 trace compounds) in the hemp oil itself, including terpenes, sugars, flavonoids, and secondary cannabinoids, that are found in all parts of hemp. We believe these compounds work together to provide the full benefits of CBD to you and your pet (read more on how using the whole plant is important).
  3. As with any supplement, start small. Give one treat to your dog and watch her reaction. If she seems to have no response, give two. Each individual dog is different and will respond differently. Be sure to follow the package directions and do not give more treats than are recommended for the weight of your dog.
  4. Try a variety of treat options. One type of treat may be formulated differently than another and you may have better success. Our Pet Releaf dog treats come in a variety of flavors and contain between 1 and 1.5 milligrams of CBD.

Dogs and CBD – Could be a great combination!

While we can’t communicate using language with our dogs, we CAN show them we love them by reducing their discomfort and providing relief when they’re struggling. We’re honored to be able to contribute to a healthy lifestyle and would love to hear about your personal pet success story with CBD. Reach out to us.


  1. Cannabis for Your Dog: How It Can Help
  3. Dogs and CBD oil – Why Hemp oil might be good for your dog
whole-plant hemp oil

Whole-plant Hemp Oil CBD vs Isolates and Nanotechnology

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You’ve heard about the ‘entourage effect,’ right?

This is the notion (more than a notion, a demonstrated truth, actually) that the various compounds and terpenes in cannabis work synergistically, amplifying each other’s power and positive benefits. Like a symphony orchestra, cannabinoids including CBD, CBN and others combine forces in ways that enable them to become greater than the sum of their parts. But the key, like that collection of orchestral instruments, is that they work together only when you are exposed to them at the same time. This orchestra of cannabinoid components is what whole-plant hemp oil provides.

That’s the genius of hemp

There is a school of thought however, that it’s better to find and isolate the key ingredient, mass produce it and then pump our bodies full of that specific molecule. Why send the infantry, artillery and the whole dang Army if you can parachute in a few specialists to who will get the job done?

Even better, by this way of thinking, we now have the technology to shrink the needed elements down to nano size. Thus, through delivery methods that bypass the stomach (sublingual tincture), you can get molecules of pure CBD isolate into your bloodstream so they can get to work. What could be better?              

Sometimes less is more

Well, as noted above, if you consume pure CBD isolate, you may well be cheating yourself out of the primary benefits whole-plant hemp oil has to offer. As explained in a post at Project CBD:

“But single-molecule CBD is less effective therapeutically than whole plant CBD-rich oil extract. Scientific studies have established that synthetic, single-molecule CBD has a very narrow therapeutic window and requires precise, high doses for efficacy, whereas lower dose, whole-plant, CBD-rich treatment regimens are already showing efficacy for many conditions among patients in medical marijuana States…

There are also many Internet storefronts touting the ‘nano technology’ they use to produce extremely small emulsified droplets that are more readily absorbed. But there are questions about this too.

From a story at TodaysDietitian.com:

“Increasing the bioavailability of nutrients and phytochemicals may be promising but is also potentially dangerous.” Mark Meskin, PhD, RD, FADA, professor emeritus of the Department of Human Nutrition & Food Science at the California State Polytechnic University in Pomona, says nanotechnology may solve absorption and solubility problems with many nutrients and phytochemicals.” But he notes that this is a clear example of technology getting well ahead of the science.”

Even though the use of nanotechnology in the dietary supplement industry may enhance supplement absorption, there is concern about the potential for toxicity. While upper limits are established for most vitamins and minerals, there are no upper limits set for non-nutrients such as phytochemicals.

“In the past, I was less concerned about phytochemical toxicity because the truth was that in many cases, very little was absorbed,” Meskin says. 

Nanotechnology raises important issues regarding safety. He explains “nanoceuticals can help bypass typical protective barriers in the body and deliver quantities of biochemicals that the body would not naturally encounter. This makes the introduction of nanoceuticals potentially dangerous, especially when the government does not regulate them effectively.”

So if nanoceuticals could be dangerous, should you be using tinctures and oils that include them? What’s the takeaway here for the consumer who wants to take advantage of the health benefits of CBD?

Educate yourself about whole-plant hemp oil and pay attention.

Despite 40,000 years of human experimentation with cannabis, only in the last 20 years have we learned about the existence of the endocannabinoid system in our bodies. Research about the effects of CBD and other cannabinoids is ongoing. Stay tuned, and in the meantime, remember this: Our bodies have a relationship with the whole plant. Therefore, stick to whole-plant hemp oil formulations like Elixinol until the research catches up with the nano trend. 

 Respira from Elixinol is made from organically grown hemp plants, and cold-processed using co2 super-critical fluid extraction. It’s PG- and PEG-free, and a THC-free, whole-plant product.  Try it today!


Why CBD Has Many Potential Uses

Why CBD Has Many Potential Uses?

By | Cannabinoids explained, Health effects of cannabinoids, How CBD works | No Comments

CBD is a Unique Molecule With Many Potential Uses

Here at Elixinol, we have covered a wide range of potential therapeutic uses for cannabidiol (CBD), other cannabinoids and hemp oil. From epilepsy to PTSD, it can all sound too good to be true. So how could one plant have so many benefits?many uses of cannabinoids

Besides being the second most abundant cannabinoid in the Cannabis genus, and the most in hemp, CBD is now well-known for the sheer number of possible therapeutic uses1. Each use has different levels of evidence, from clinical trials where we see how effective it is in humans, to in vitro lab studies where we can see how it may work. The presence of endocannabinoid receptors in a range of tissues and organs help to explain CBD’s broad applications. However, it can also interact with other types of receptors in the body and brain.

The brain seems to be built for cannabinoids

Endocannabinoid-CBD-PTSDThe brain is made up of billions of highly specialised cells called neurons, along with several types of supporting cell2. Each neuron communicates with many other neurons by the synapses. Synapses are where two tiny bulbs on the ends of projections from the neuron cell come to meet. Neurons communicate with these by using chemicals known as neurotransmitters. Whether or not a neuron can “understand” the use of a certain neurotransmitter depends on if it has a receptor for that chemical. These receptors can respond to other chemicals too, such as the cannabinoids.

CBD increases the level of our own Cannabinoids

CBD, unlike THC, does not directly interact with the cannabinoid receptors, but instead works to increase the levels of our own cannabinoids. It also indirectly affects the signaling of these receptors. One of the non-cannabinoid receptors that CBD can influence is the dopamine receptors. Dopamine is involved with motivation and reward, as well as other cognitive and motor functions. This may be behind how CBD could help to fight cigarette cravings. In a study of 24 cigarette smokers, volunteers were given either an inhaler with CBD, or a placebo inhaler, and instructed to use it whenever they craved a cigarette3. The number of cigarettes smoked in the CBD group dropped significantly during the week, but not for the placebo group.

CBD and Serotonin

Animal studies have also shown that CBD can interact with some types of serotonin receptors, which may explain its effects on depression and anxiety. Its ability to interact with the serotonin 1A receptor may explain the documented effects of CBD on neuropathic pain, opioid dependence, and nausea and vomiting. There have been many anecdotal reports of hemp oil relieving nausea, even in severe vomiting caused by pharmaceuticals used for cancer. In addition, a study on shrews showed an effect of CBD on the serotonin 1A receptors which significantly reduced nausea and vomiting4. Its non-heated form, CBDA, had the same effect, but at a much lower dose.

Supporting the wide-ranging effects of CBD are the other cannabinoids, such as CBG and CBC, terpenes and other phytochemicals. These have shown anti-inflammatory, antidepressant, antioxidant and other effects. Why CBD has many potential potential uses and benefits can be seen in the number of applications it seems to be successful in. The benefits and uses of hemp oil and CBD aren’t “too good to be true,” but they are very promising though clinical trials are needed to confirm many of them.

Why CBD Has Many Potential Uses


1: https://www.leafly.com/news/science-tech/what-does-cbd-do

2: Tortora & Derrickson, 2012, Principles of Anatomy & Physiology, 12th edn, Wiley

3: http://www.ncbi.nlm.nih.gov/pubmed/23685330

4: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960260/

5: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/


What is a Liposome and How Could it Improve CBD Absorption?

By | Cannabinoids explained, How CBD works | One Comment

Tinictures, oral sprays, skin cream, liposomes? If you’re new to the world of hemp, the variety of ways to take just one plant’s extract may be a little confusing. What method of dosage is best? Also, what do terms such as “liposome” even mean? If you have noticed liposomal sprays in Elixinol’s product range and are interested in trying hemp extract liposomes, it’s worth knowing what you’re getting, and why they are made that way. Read More

Hemp Oil Uses

Hemp Oil Uses & Dіеtаrу Benefits

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Hеmр oil uses are extremely varied. Hemp seed oil, ехtrасtеd dіrесtlу frоm thе sееds of industrial hemp, іs mоstlу used for bоdу саrе рrоduсts, оr іndustrіаllу іn lubrісаnts, fuеls, раіnts аnd рlаstісs. Ноwеvеr, thе bеnеfіts оf соnsumіng hеmр sееd оіl also саnnоt bе іgnоrеd. Read More

drug test cbd

Will I Pass a Drug Test if I Take CBD Hemp Extracts?

By | Cannabis Legislation, How CBD works | 8 Comments

The difference between many medicinal hemp products and recreational cannabis is that the former can contain little to no THC, the psychoactive component of cannabis.  A common concern among many who use hemp extracts is the possibility of testing positive for cannabis use in the workplace or at a roadside drug test. This could mean facing legal action, unemployment or both.

Are these fears unfounded or must we wait for clear legalisation before starting any form of medicinal hemp / CBD oil? Read More

How Does Cannabidiol (CBD) Work?

By | How CBD works | 11 Comments

Before making the decision to buy CBD oil, I strongly recommend you to take the time to learn more about cannabidiol and our product and to get familiar with the numerous benefits of cannabinoids on the human body. We’ve already discussed some of these benefits in previous articles, so right now it’s time to take a closer look at how does CBD work inside the human body.

CBD’s action inside the body

CBD or cannabidiol is the main active compound in hemp and unlike THC, it is not psychoactive, so it doesn’t make you high. As you may know, inside the human body there’s the endocannabinoid system, with receptors spread throughout the brain and body. THC activates the CB1 and CB2 receptors, while CBD does not directly stimulate these receptors. Read More